According to researchers, a combination of invasive coronary angiography (ICA) and stress tests with single photon emission tomography (SPECT) myocardial imaging has been the gold standard for making these determinations, with ICA showing the blockages and SPECT the perfusion, or penetration of the blood into the tissue.
“Previous studies show that a lesion is hemodynamically significant if there is a noteworthy blood pressure drop corresponding to a big reduction in blood flow across the stenosis,” said study author Joao A.C. Lima.
“If plaque has those characteristics, the patient should be targeted for intervention, be it with a stent or downstream bypass surgery.”
The researchers set out to determine if combined CT angiography (CTA) and CT myocardial stress perfusion imaging (CTP) could demonstrate similar or superior ability to ICA/SPECT in predicting future adverse events.
“Invasive angiography is generally safe, but it can cause vascular problems in a significant number of patients, most commonly at site of the puncture,” Lima said.
“Now with just one noninvasive test we can get two important but different pieces of information about the coronary arteries,” said co-author Marcus Chen.Recommended By Colombia
They compared the invasive and noninvasive approaches on 379 patients, who were referred for ICA, from November 2009 to July 2011.